Distribution pattern of dorsal root ganglion neurons synthesizing nitric oxide synthase in different animal species
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منابع مشابه
cGMP-dependent protein kinase in dorsal root ganglion: relationship with nitric oxide synthase and nociceptive neurons.
Nitric oxide and cGMP influence plasticity of nociceptive processing in spinal cord. However, effectors for cGMP have not been identified in sensory pathways. We now demonstrate that cGMP-dependent protein kinase I (cGKl) occurs in the DRGs at levels comparable to that in cerebellum, the richest source of cGKl in the body. Immunohistochemical studies reveal that cGKl is concentrated in a subpop...
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Yoshimura, Naoki, Satoshi Seki, and William C. de Groat. Nitric oxide modulates Ca channels in dorsal root ganglion neurons innervating rat urinary bladder. J Neurophysiol 86: 304–311, 2001. The effect of a nitric oxide (NO) donor on high-voltage-activated Ca channel currents (ICa) was examined using the whole cell patch-clamp technique in L6–S1 dorsal root ganglion (DRG) neurons innervating th...
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The effect of a nitric oxide (NO) donor on high-voltage-activated Ca(2+) channel currents (I(Ca)) was examined using the whole cell patch-clamp technique in L(6)-S(1) dorsal root ganglion (DRG) neurons innervating the urinary bladder. The neurons were labeled by axonal transport of a fluorescent dye, Fast Blue, injected into the bladder wall. Approximately 70% of bladder afferent neurons exhibi...
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Background and Objective: Sensory neurons have critical role in improvement of functional outcome of any neuroprotective strategy. The herbal medicine Nepeta menthoides has been reported to have anti-apoptotic effect on axotomized spinal motoneurons. In the present study, the putative neuroprotective effect of Nepeta menthoides on the axotomized dorsal root ganglion sensory neurons in neonate r...
متن کاملAdrenomedullin protects rat dorsal root ganglion neurons against doxorubicin-induced toxicity by ameliorating oxidative stress
Objective(s): Despite effective anticancer effects, the use of doxorubicin (DOX) is hindered due to its cardio and neurotoxicity. The neuroprotective effect of adrenomedullin (AM) was shown in several studies. The present study aimed to evaluate the possible protective effects of AM against DOX-induced toxicity in dorsal root ganglia (DRGs) neurons. M...
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ژورنال
عنوان ژورنال: Canadian Journal of Physiology and Pharmacology
سال: 2017
ISSN: 0008-4212,1205-7541
DOI: 10.1139/cjpp-2016-0294